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目的:探讨在综合性基础治疗的基础上加用普米克联合孟鲁司特治疗小儿慢性咳嗽的疗效。方法:将136例慢性咳嗽患儿随机分为3组,对照组(n=44)按综合性基础治疗,包括按常规给予抗生素、止咳、扩张支气管等药物治疗,治疗A组(n=47)在综合性基础治疗的基础上加用普米克令舒雾化吸入,10～15 min/次,2次/d,治疗组B组(n=45)在治疗A组的基础上,加用孟鲁司特,疗程为1周。结果:对照组44例患儿中11例有效,总有效率为45.5%,治疗A组47例患儿中21例有效,总有效率为70.2%,治疗B组45例患儿中30例有效,总有效率为88.9%。治疗A组的总有效率与对照组比较,治疗B组总有效率与治疗A组比较差异均有统计学意义(χ2=5.73,χ2=4.89,P<0.05);治疗B组总有效率与对照组比较,差异有统计学意义(χ2=19.11,P<0.01)。结论:普米克令舒联合孟鲁司特辅助治疗小儿慢性咳嗽疗效确切,而且简单、安全。
Objective: To investigate the curative effect of Pulmicort combined with montelukast on children with chronic cough on the basis of comprehensive basic treatment. Methods: A total of 136 children with chronic cough were randomly divided into three groups. The control group (n = 44) was treated with a combination of basic treatment including antibiotics, cough and bronchial expansion. The patients in group A (n = 47) On the basis of comprehensive basic treatment plus Pulmicort Respiratory inhalation, 10 ~ 15 min / time, 2 times / d, the treatment group B (n = 45) on the basis of the treatment group A, plus Meng Lu Stewart, treatment for 1 week. Results: Of the 44 children in the control group, 11 were effective and the total effective rate was 45.5%. Among the 47 children in the treatment group A, 21 were effective and the total effective rate was 70.2%. Among 45 children in the treatment group B, 30 were effective , The total effective rate was 88.9%. The total effective rate of treatment group A compared with the control group, the total effective rate of treatment group B and treatment group A difference was statistically significant (χ2 = 5.73, χ2 = 4.89, P <0.05); the total effective rate of treatment group B and The difference between the two groups was statistically significant (χ2 = 19.11, P <0.01). Conclusion: The combination of pulmicort and montelukast in children with chronic cough is effective, simple and safe.