面对多重耐药菌的流行和扩散,临床对新的抗菌药物需求非常迫切。新一类甘氨酰四环素类抗生素新近问世,其首个上市药物替加环素对革兰阳性或革兰阴性菌均具有广谱抗菌活性,特别是对临床某些重要的耐药菌具有很高的活性。已有临床研究显示,替加环素疗效和耐受性均良好可用于复杂性成人腹腔感染(cIAI)和复杂性皮肤及软组织感染(cSSSI)。 Faced with the prevalence and proliferation of multi-resistant bacteria, the clinical demand for new antimicrobial drugs is very urgent. A new class of glycylcycline antibiotics recently came out, the first listed drug tigecycline on Gram-positive or Gram-negative bacteria have broad-spectrum antibacterial activity, especially for some important clinical drug-resistant bacteria have very High activity. Clinical studies have shown that tigecycline is well-tolerated and tolerable for complex celiac ascites (cIAI) and complicated skin and soft tissue infections (cSSSI) in adults.