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目的评估MTHFR基因多态性与早产、阴性妊娠结局和低出生体重的关系。方法随机选取200例早产儿(17例不足28w的极早早产儿、35例28w到不足32w的早期早产儿、148例32w到不足37w的轻型早产儿)和200例足月分娩儿参与研究。使用PCR-RFLP法检测早产和足月生产组MTHFR(C677T)基因多态性。结果 MTHFR基因多态性与早产、阴性妊娠结局(死胎)和低出生体重显著相关。MTHFR基因多态性显著增加了极早早产(P<0.001,χ~2=11.23)、早期早产(P<0.001,χ~2=11.93)和轻型早产(P<0.001,χ~2=12.06)发生的风险。但MTHFR基因多态性只显著增加了极早早产儿死亡(P=0.002,χ~2=5.43)和低出生体重(P=0.009,χ~2=6.23)的风险,与早期早产儿和轻型早产儿的死亡和低出生体重无关。结论 MTHFR(C677T)基因多态性是早产、阴性妊娠结局(死胎)和低出生体重易感性的遗传危险因素。MTHFR(C677T)可以作为妊娠患者早产的预后指标,控制患早产的风险。
Objective To assess the association of MTHFR gene polymorphisms with preterm birth, negative pregnancy outcomes and low birth weight. Methods A total of 200 preterm infants (17 very early premature infants less than 28 weeks, 35 early premature infants between 28w and less than 32w, 148 mild premature infants between 32w and less than 37w) and 200 full term infants were included in the study. PCR-RFLP was used to detect polymorphisms of MTHFR (C677T) gene in preterm and term infants. Results MTHFR gene polymorphism was significantly associated with preterm birth, negative pregnancy outcome (stillbirth) and low birth weight. MTHFR gene polymorphism significantly increased the rate of very early preterm birth (P <0.001, χ ~ 2 = 11.23), early preterm birth (P <0.001, χ ~ 2 = 11.93) The risk of happening. However, MTHFR gene polymorphism significantly increased the risk of very early preterm infant death (P = 0.002, χ ~ 2 = 5.43) and low birth weight (P = 0.009, χ ~ 2 = 6.23) Children’s death has nothing to do with low birth weight. Conclusions MTHFR (C677T) gene polymorphism is a genetic risk factor for premature delivery, negative outcome of pregnancy (stillbirth) and susceptibility to low birth weight. MTHFR (C677T) can be used as a prognostic indicator of preterm birth in pregnant women to control the risk of preterm birth.