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目的探讨慢性阻塞性肺疾病(COPD)稳定期患者血清α1-抗胰蛋白酶(α1-AT)质量浓度与气道炎症及肺功能的相关性。方法入选60例稳定期COPD患者及30例健康对照者,检测了入选对象的血清α1-AT、白介素-6(IL-6)、白介素-8(IL-8)、中性粒细胞弹性蛋白酶(NE)水平,并对60例COPD患者进行了肺功能检测。结果COPD患者血清α1-ATI、L-6I、L-8、NE水平均明显高于对照组,α1-AT质量浓度与NE水平正相关;COPD患者血清α1-AT质量浓度与肺功能残气量/肺总量(RV/TLC)明显负相关。结论稳定期COPD患者慢性气道炎症持续存在,血清α1-AT质量浓度与气道炎症程度正相关,与肺气肿程度负相关。
Objective To investigate the relationship between serum α1-antitrypsin (α1-AT) and airway inflammation and pulmonary function in patients with chronic obstructive pulmonary disease (COPD) at stable phase. Methods Sixty stable COPD patients and 30 healthy controls were enrolled in the study. Serum levels of α1-AT, IL-6, IL-8 and neutrophil elastase NE) levels, and 60 patients with COPD lung function tests. Results The serum level of α1-ATI, L-6I, L-8 and NE in COPD patients were significantly higher than those in control group. The concentration of α1-AT was positively correlated with NE level. The serum level of α1- Total lung volume (RV / TLC) was significantly negatively correlated. Conclusion Chronic airway inflammation persists in patients with stable COPD. The serum level of α1-AT is positively correlated with the degree of airway inflammation and negatively correlated with the degree of emphysema.