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羰铂(JM8)是一种顺铂类似物。先期进行的临床研究证明,与顺铂相比,羰铂的优点在于无明显肾毒性,较少引起呕吐和听力损失。作者研究了羰铂对56名经组织学或细胞学证实的小细胞肺癌病人的疗效和毒性。56人中,男34人,女22人,年龄35～79岁;16人为局限性病变,40人为广泛性病变。30人以前未接受过化疗(其中21人因肿瘤已广泛扩散,5人因年迈、全身情况差,4人因顾忌发生脱发)。其余26人中,9人对以前的传统化疗无效,17人曾有效,但以后肿瘤复发。剂量和疗程:30人为400mg/m~2,23人为300mg/m~2。(因骨髓浸润,年龄>70岁,或~(51)铬-EDTA 廓清率降低25%以上),3人为250mg/m~2(因严重骨髓浸润伴周围血小板减
Carboplatin (JM8) is a cisplatin analog. Previous clinical studies have demonstrated that compared with cisplatin, carbonyl platinum has the advantages of no significant nephrotoxicity and less vomiting and hearing loss. The authors studied the efficacy and toxicity of carbonylplatinum in 56 patients with histologically or cytologically proven small cell lung cancer. Of the 56 people, 34 were males and 22 were females, aged 35-79 years; 16 were localized lesions and 40 were extensive lesions. Thirty people had not previously received chemotherapy (21 of them had been widely spread due to tumors, 5 of them were old, had poor general conditions, and 4 had hair loss due to scruples). Of the remaining 26 people, 9 had no effect on the previous conventional chemotherapy, 17 had been effective, but later the tumor recurred. Dosage and duration of treatment: 400 mg/m2 for 30 people and 300 mg/m2 for 23 patients. (Because of bone marrow infiltration, older than 70 years old, or ~(51) chromium-EDTA clearance rate decreased by more than 25%), 3 were 250 mg/m~2 (due to severe bone marrow infiltration with peripheral thrombocytopenia