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每日应用1次大剂量(0.6克)异烟肼,静注与口服各半,并联用对氨水杨酸钠和链霉素,共治疗病情较重的初治和早期复治肺结核患者119例。治疗6个月后痰菌阴转率为89％,空洞关闭率为73％,病灶明显吸收率为54％,无明显毒副反应。作者认为本方案对治疗痰菌阳性或有空洞、或病灶广泛的较重的初治以及初治失败的早期复治病例有良好疗效,并讨论了每日1次大剂量异烟肼治疗肺结核的实验和临床依据。
A large dose (0.6 g) of isoniazid is administered daily, and the mice are also treated with pamidronate and streptomycin in combination with intravenous and oral administration in a total of 119 cases of newly diagnosed and early retreatment tuberculosis . After 6 months of treatment, the sputum negative conversion rate was 89%, the void closure rate was 73%, and the apparent absorption rate of the lesions was 54% with no obvious side effects. The authors believe that the program for the treatment of sputum positive or empty, or extensive extensive initial treatment and early re-treatment fails early re-treatment of cases have a good effect, and discusses a large daily dose of isoniazid for the treatment of pulmonary tuberculosis Experimental and clinical basis.