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探讨乳腺癌与血浆D-二聚体水平的相关性。对我院收治的乳腺癌及良性乳腺病患者手术前后的血浆D-二聚体水平进行检测,并与健康女性血浆D-二聚体水平进行对比分析。术前乳腺癌组患者的D-二聚体水平及阳性率均明显高于良性乳腺病组及健康组(P<0.05和P<0.01);D-二聚体浓度、阳性率随病变的恶性程度升高而有上升趋势(P<0.05和P<0.01);Ⅰ期、Ⅱ期乳腺癌患者术后D-二聚体改善程度明显高于Ⅲ期乳腺癌患者(P<0.01)。血浆D-二聚体浓度可作为临床上预测乳腺癌患者临床分期及预后的一项重要指标。
To investigate the correlation between breast cancer and plasma D-dimer level. The levels of plasma D-dimer before and after surgery in patients with breast cancer and benign breast disease admitted to our hospital were measured and compared with the level of plasma D-dimer in healthy women. D-dimer level and positive rate in patients with preoperative breast cancer were significantly higher than those in benign breast disease group and healthy group (P <0.05 and P <0.01). The concentration of D-dimer and the positive rate were positively correlated with the malignancy (P <0.05 and P <0.01). The improvement of postoperative D-dimer in patients with stage I and stage II breast cancer was significantly higher than that in stage III breast cancer patients (P <0.01). Plasma D-dimer concentration can be used as a clinical prediction of clinical stage and prognosis of breast cancer is an important indicator.