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目的探讨促红细胞生成素(EPO)和血红蛋白(Hb)与慢性心力衰竭(CHF)的相关性。方法选择老年CHF患者1 69例,根据本次住院确诊的心功能(NYHA)Ⅰ、Ⅱ、Ⅲ和Ⅳ级依次分为1组33例、2组34例、3组59例和4组4 3例。对4组患者Hb、EPO及是否死亡进行logistic回归分析。结果与1组比较,2、3和4组lg EPO水平明显上升,Hb水平明显下降(P<0.01);4组患者lg EPO和Hb水平两两比较,差异均有统计学意义(P<0.01)。Hb、EPO及肌酐(OR=0.978,35.820,1.013,P<0.01)均是影响老年CHF患者住院死亡的危险因素。结论 EPO随患者CHF程度的加重而升高,Hb值则降低。Hb、EPO及肌酐均为影响CHF患者住院死亡的危险因素。
Objective To investigate the relationship between erythropoietin (EPO) and hemoglobin (Hb) and chronic heart failure (CHF). Methods One hundred and seventy-nine elderly patients with CHF were enrolled in this study. According to NYHA Ⅰ, Ⅱ, Ⅲ and Ⅳ levels, 33 cases were divided into 1 group, 34 cases in 2 cases, 59 cases in 4 cases and 4 cases in 4 groups example. Logistic regression analysis was performed on Hb, EPO and death in 4 patients. Results Compared with the first group, the level of EPO in 2, 3 and 4 groups increased significantly and the level of Hb decreased significantly (P <0.01). The EPO and Hb levels in all groups were statistically significant (P <0.01) ). Hb, EPO and creatinine (OR = 0.978, 35.820, 1.013, P <0.01) were the risk factors of in-hospital mortality in elderly patients with CHF. Conclusions EPO increased with the severity of CHF and Hb decreased. Hb, EPO and creatinine are the risk factors of in-hospital mortality in CHF patients.