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皮肤毒性坏死,即Lyell’s综合症,是药物所致的最严重的付作用之一.死亡率约为22%.任何对某种药物有过敏反应病史的病人再次接触它可能是危险的.病例报告:男、66岁,手术切除蝶骨脑膜瘤患者.术前2个月只有一次全身性癫痫发作,术后给与口服苯妥英纳300～400mg/日.术后18天因患肺炎使用抗生素.3天后体温达39.6℃,皮肤发红,皮疹融合.停用抗生素,同时静脉注射强地松龙100mg.5天后全身性大发作一次.又5天后全身大部分皮肤出现皮疹,并在耳,腿和躯干出现水疱.停用苯妥英钠.随着舌头和咽部出现水肿病人发生
Toxic skin necrosis, known as Lyell’s syndrome, is one of the most serious drug-related side effects with a mortality rate of about 22%. Any patient who has a history of an allergic reaction to a drug may be in danger of re-exposure to it. : Male, 66 years old, with surgical excision of sphenoid meningioma, with only one episode of seizures two months prior to surgery and 300 to 400 mg orally administered phenytoin postoperatively. Antibiotics were used for pneumonia 18 days after surgery.3 Days after the body temperature of 39.6 ℃, skin redness, skin rash fusion. Disable antibiotics, while intravenous injection of prednisolone 100mg.5 days after a major episode .5 days after most of the skin rash appeared in the body, and ears, legs and Trunk blisters. Disable phenytoin. With the occurrence of edema in the tongue and pharynx occurs