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目的：研究强心扩血管新药羟苯氨酮（ｏｘｙｐｈｅｎａｍｏｎｅ）对心力衰竭的治疗作用。方法：用多导生理仪与电磁流量计测定戊巴比妥钠致心力衰竭豚鼠、猫与狗的心脏血流动力学参数。结果：ｉｖ羟苯氨酮１～８ｍｇ·ｋｇ－１，剂量依赖性地增加心肌收缩力、左室收缩压、心输出量、心脏作功及冠状动脉血流量，其作用强度与磷酸二酯酶抑制剂（ＰＤＥＩ）氨力农（ａｍｒｉｎｏｎｅ）相似。而ＰＤＥＩ增加心率，易致心律失常，并继续降低血压；羟苯氨酮则减慢心率，使降低的血压上升。结论：羟苯氨酮能明显改善心衰动物的心脏功能，其作用优于ＰＤＥＩ，有可能发展成为治疗心力衰竭的新药。
Objective: To study the therapeutic effect of cardiotoxic vasodilator new-drug oxyphenamone on heart failure. Methods: Cardiac hemodynamic parameters of heart failure guinea pig, cat and dog induced by pentobarbital sodium were determined by multi-conductance physiology and electromagnetism flowmeter. Results: IV oxyphenamone 1 ~ 8mg · kg-1, a dose-dependent increase in myocardial contractility, systolic blood pressure, cardiac output, cardiac work and coronary blood flow, the intensity of interaction with phosphodiesterase Inhibitors (PDEIs) Amrinone is similar. PDEI increased heart rate, prone to cause arrhythmia, and continue to lower blood pressure; oxycodone slows heart rate, lower blood pressure. Conclusions: Oxyphenamone can significantly improve the heart function of heart failure animals, its effect is better than that of PDEI, which may develop into a new drug for the treatment of heart failure.