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作者报告急性心肌梗塞(AMI)患者早期使用卡托普利,随访2个月观察其对左心室(LV)重构的影响。在此双盲试验中,将99例患者(男82例,女17例,年龄40～75岁)随机分为用药组或安慰剂组。全部患者的Mo-rris记分>3.5,入院时收缩压>12.7 kPa,无明显的肾脏或脑血管病变,没有使用血管紧张素转换酶抑制剂的指征,也没有使用本药的反指征。患者入院后即服用初始剂量6.25mg,1小时后再服用1次,8小时后再服12.5mg;以后每日3次,每次12.5mg;直至每日3次,每次25mg。如果收缩压持续<11.3kPa,则停药 1次,以后半量用药,减量后收缩压仍持续<11.3 kPa,则将其从研究组中撤去;减量后尿素>20mmol/L或发生
The authors report that early use of captopril in patients with acute myocardial infarction (AMI), followed up for 2 months to observe the impact of left ventricular (LV) remodeling. In this double-blind trial, 99 patients (82 males and 17 females, aged 40-75 years) were randomized to either placebo or placebo. All patients had Mo-rris score> 3.5, systolic blood pressure> 12.7 kPa on admission, no significant renal or cerebrovascular disease, no indication of angiotensin-converting enzyme inhibitors, and no anti-sign of the drug. Patients admitted to the hospital after taking the initial dose of 6.25mg, 1 hour after taking 1, 8 hours after serving 12.5mg; after 3 times daily, each 12.5mg; until 3 times daily, each time 25mg. If the systolic blood pressure continued to <11.3kPa, the drug was discontinued once and half of the dose was taken later, and the systolic blood pressure was reduced to <11.3 kPa, then it was withdrawn from the study group. Reduced urea> 20 mmol / L occurred