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目的:检测冠心病患者炎症标志物浓度,并探讨其在冠心病冠状动脉粥样硬化(As)中的作用。方法:用酶联免疫吸附试验检测冠心病患者血清中肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)的浓度,用散射免疫比浊法检测冠心病患者血清中C反应蛋白(CRP)的浓度,并与正常对照组比较。结果:冠心病患者不稳定性心绞痛组和急性心肌梗死组TNF-αI、L-6和CRP浓度比正常对照组和冠心病患者稳定性心绞痛组显著升高(P<0.05或P<0.01);稳定性心绞痛组TNF-αI、L-6和CRP浓度比正常对照组高,但无显著差异(P>0.05)。结论:炎症标志物TNF-αI、L-6和CRP间相互作用,可能共同参与冠心病冠状动脉粥样硬化的发生发展过程,监测其浓度变化对冠心病有重要意义。
Objective: To detect the concentration of inflammatory markers in patients with coronary heart disease and to explore its role in coronary atherosclerosis (As). Methods: Serum levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in patients with coronary heart disease were measured by enzyme linked immunosorbent assay (ELISA) C-reactive protein (CRP) concentrations, and compared with the normal control group. Results: The concentrations of TNF-αI, L-6 and CRP in unstable angina pectoris group and acute myocardial infarction group were significantly higher than those in control group and coronary heart disease group (P <0.05 or P <0.01). The concentrations of TNF-αI, L-6 and CRP in stable angina group were higher than those in normal control group, but there was no significant difference (P> 0.05). Conclusion: The interaction between inflammatory markers TNF-αI, L-6 and CRP may participate in the occurrence and development of coronary atherosclerosis in coronary heart disease. It is important to monitor the changes of concentrations of TNF-αI, L-6 and CRP in coronary heart disease.