目的:研究不同壳聚糖膜在体外及体内的生物降解时间。方法:用不同分子量壳聚糖为制膜材料,将4组不同组成成分的壳聚糖溶于1.5%乙酸中,配成1%溶液,加入辅料烘干成膜称其重量,剪成大小相等的小块,精称后放置于弱酸介质和雌鼠阴道中。定时取样,水洗,烘干后称重,按W-W’W×100%算得降解百分率。结果:1号较2号降解时间快,而加入PVA的3号与4号又较1号与2号更快。结论:壳聚糖是一种生物可降解材料,壳聚糖膜的降解时间与其分子量、PVA比例、介质酸性强度等因素相关。 Objective: To study the biodegradation time of different chitosan membranes in vitro and in vivo. Methods: Chitosan with different molecular weight was used as membrane-forming material. Four groups of chitosan with different compositions were dissolved in 1.5% acetic acid to make a 1% solution. Of the small, accurate after placed in a weak acid medium and female vagina. Timing sampling, washing, weighing after drying, calculated by W-W’W × 100% degradation percentage. Results: No. 1 was faster than No. 2 and PVA No. 3 and No. 4 were faster than those No. 1 and No. 2. Conclusion: Chitosan is a biodegradable material. The degradation time of chitosan film is related to its molecular weight, PVA ratio and acid strength of medium.