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目的:探讨凋亡抑制蛋白因子Livin在结肠癌组织中的表达及其与结肠癌发生发展的各临床病理因素之间的关系。方法:收集2008年10月—2012年4月经手术切除且病理证实的95例结肠癌患者临床资料,记录患者性别、年龄、分化程度、浸润程度、淋巴结转移情况及TNM分期等各项临床相关资料。应用免疫组化方法检测Livin在95例结肠癌患者肠组织中的表达情况。结果:Livin在结肠癌中表达阳性率46.32%(44/95),明显高于对照组的12.82%(5/39);Livin基因表达与患者性别、年龄、肿瘤病灶大小、是否有远处转移均无关(P>0.05);与是否有淋巴结转移、TNM分期、分化程度及浸润深度有关(P<0.05)。结论:检测Livin在结肠癌组织中的表达对结肠癌的临床诊断、病情评估、治疗及预后可提供重要指导。
OBJECTIVE: To investigate the expression of Livin, an inhibitor of apoptosis protein, in colon cancer tissues and its relationship with clinicopathological factors in the development of colon cancer. METHODS: The clinical data of 95 patients with colon cancer who were surgically removed and confirmed by pathology from October 2008 to April 2012 were collected. The clinically relevant data such as gender, age, differentiation, infiltration, lymph node metastasis and TNM stage were recorded . Immunohistochemistry was used to detect the expression of Livin in 95 cases of colon cancer patients. Results: The positive rate of Livin expression in colon cancer was 46.32% (44/95), which was significantly higher than that in the control group (12.82%, 5/39). The expression of Livin was related to the gender, age, tumor size, distant metastasis (P> 0.05). There was a correlation between lymph node metastasis, TNM stage, differentiation and depth of invasion (P <0.05). Conclusion: Detecting the expression of Livin in colon cancer tissue can provide important guidance for the clinical diagnosis, condition evaluation, treatment and prognosis of colon cancer.