炼油厂大型化是由装置大型化实现的， 而装置大型化的关键是解决大型工艺设备的单元过程、设备制造安装及它们之间优化配置等问题。为此必须开展有关化学工程、大型设备开发和工程设计的研究。化学工程研究的目的是提高大型单元设备的可操作性和效率。大型设备开发主要是就设备的材料选择、设计、制造和安装的特殊要求进行研究。工程设计研究旨在将大型装置组合成有机整体， 确保较高的产品收率、较低的物耗和能耗， 以及长周期安全运转。为炼制高含硫原油， 则须研究防腐措施， 开发防腐材料和防腐设备。 Large-scale refinery is achieved by the large-scale devices, and large-scale device is the key to solve large-scale process equipment unit process, equipment manufacturing and installation and optimization between the allocation of such issues. To this end must carry out the chemical engineering, large equipment development and engineering design research. The purpose of chemical engineering research is to improve the operability and efficiency of large unit equipment. The development of large equipment mainly focuses on the special requirements of equipment selection, design, manufacture and installation. Engineering design studies are designed to combine large installations into an organic whole, ensuring high product yields, lower material and energy consumption, and long-term safe operation. To refine high-sulfur crude oil, anti-corrosion measures must be studied to develop anti-corrosion materials and anti-corrosion equipment.