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BLyS是肿瘤坏死因子家族新成员,由285个氨基酸组成,为Ⅱ型跨膜蛋白。BLyS可刺激B淋巴细胞增殖、分化和分泌抗体,在机体的体液免疫中发挥重要调节作用。BLyS表达失衡与多种自身免疫性疾病的发生有关。
BLyS, a new member of the tumor necrosis factor family, consists of 285 amino acids and is type II transmembrane protein. BLyS can stimulate B lymphocyte proliferation, differentiation and secretion of antibodies, play an important regulatory role in the body’s humoral immunity. The unbalance of BLyS expression is related to the occurrence of many autoimmune diseases.