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目的:统计住院围产儿出生缺陷的发生情况及影响因素,寻找预防出生缺陷的措施。方法:收集2006年1月1日～2011年12月31日福建省新生儿救护中心厦门分中心住院围产儿13 898例中发生出生缺陷的临床资料,对患儿出生缺陷构成状况、孕妇多种相关因素进行回顾性分析。结果:6年间福建省新生儿救护中心厦门分中心住院患儿出生缺陷发生率为22.45‰(312/13 898)。出生缺陷按不同组织器官及部位划分,位于前5位依次为心血管系统、四肢畸形、肾脏发育异常、尿道下裂、颌面部畸形。结论:大力实施围产期新生儿出生缺陷监测与干预工作,积极开展围产保健、避免早孕期高危因素的暴露、提高产前筛查和诊断技术对降低出生缺陷发生率有指导意义。
OBJECTIVE: To analyze the incidence and influencing factors of birth defects in hospitalized infants, and find out the measures to prevent birth defects. Methods: The clinical data of 13 898 hospitalized perinatal infants in the Xiamen Newborn Rescue Center in Fujian Province from January 1, 2006 to December 31, 2011 were collected. The incidence of birth defects, the number of pregnant women Related factors were retrospectively analyzed. Results: The incidence of birth defects in hospitalized children in Fujian Center for Newborn Care in Xiamen in 6 years was 22.45 ‰ (312/13 898). The birth defects were classified according to different tissues, organs and parts. The top five were birth defects of cardiovascular system, limb deformity, abnormal kidney development, hypospadias, maxillofacial deformity. CONCLUSION: Vigorously implement the monitoring and intervention of birth defects in perinatal neonates, actively carry out perinatal care, avoid exposure of risk factors in early pregnancy, and improve prenatal screening and diagnosis techniques to reduce the incidence of birth defects.