CD200是免疫球蛋白超家族的一种膜糖蛋白,可表达于B细胞及其增殖性疾病和一部分T细胞。作者以往研究发现,在结节性淋巴细胞为主型霍奇金淋巴瘤中环绕于L&H细胞周围的T细胞表达CD200,而此T细胞亦表达PD-1和CXCL13,与生发中心内辅助性T细胞的免疫表型相同。基于此,作者在本研究中使用免疫组化套染方法显示,在反应性淋巴组织中CD200可表达于生发中心内辅助T细胞。而 CD200 is a membrane glycoprotein of the immunoglobulin superfamily that is expressed on B cells and their proliferative diseases and on a subset of T cells. The authors previously found that CD200 is expressed on T cells surrounding L & H cells in nodular lymphocyte predominant Hodgkin’s lymphoma and that this T cell also expresses PD-1 and CXCL13, which is associated with a secondary T The same immunophenotype of cells. Based on this, the authors used immunohistochemical staining in this study to show that CD200 can express helper T cells within the germinal center in reactive lymphoid tissue. and