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Ⅰ型生长因子受体家族(即表皮生长因子受体相关家族)包括c-erbB-1(或HER-1,表达产物为EGFR)、c-erbB-2(或neu、HER-2)、c-erbB-3(或HER-3)、c-erbB-4(或HER-4)四种原癌基因,分别编码不同的跨膜蛋白酪氨酸激酶。它们的蛋白具有相似的结构:都由与特定配体结合的胞外区、转膜区和胞内酪氨酸激酶结构区三部分组成。在特异性功能区即激酶区有着相同的氨基酸序列,表明有着共同的起源。在功能上,它们主要参与细胞信号的传导;带有细胞生长信号的特异性配体与上述受体结合,或受体本身的异常改变,使酪氨酸激酶被激活,受体聚合,发生自身磷酸化,始动胞液内的级联蛋白磷酸化反应,从而改变了效应器的活性。其效应器包括许多与细胞增殖、分化有关的因子和其
Type I growth factor receptor family (ie epidermal growth factor receptor related family) includes c-erbB-1 (or HER-1, expression product is EGFR), c-erbB-2 (or neu, HER-2), c The four oncogenes -erbB-3 (or HER-3) and c-erbB-4 (or HER-4) encode different transmembrane protein tyrosine kinases. Their proteins have similar structures: they consist of three parts: the extracellular region that binds to a specific ligand, the transmembrane region, and the intracellular tyrosine kinase structural region. The same amino acid sequence in the specific functional region, the kinase region, indicates a common origin. Functionally, they are mainly involved in the transmission of cell signals; specific ligands with cell growth signals bind to these receptors, or abnormal changes in the receptor itself, activate tyrosine kinases, and receptors aggregate, producing their own Phosphorylation initiates the phosphorylation of the cascade protein in the cytosol, thereby altering the effector activity. Its effectors include many factors related to cell proliferation and differentiation and its