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目的观察盐酸米诺环素预防干槽症的疗效。方法选择2009年2月至2011年10月在本科拔除下颌智齿的患者106例,随机分为观察组和对照组各53例。观察组拔牙后,剪一块2cm×2cm大小的生物止血绵,表面涂上适量的盐酸米诺环素软膏置于拔牙窝内,咬纱卷半小时。止血后吐出纱卷,附有软膏的止血绵留置拔牙窝内,待其自行脱落;对照组只咬纱卷止血,拔牙窝内不使用预防性药物,术后口服3d阿莫西林和甲硝唑。结果观察组53例中未发生一例干槽症,一周后复诊,拔牙创表面全部愈合,有效率100%。对照组53例中发生干槽症5例,有效率90.1%。两组有效率比较,差异有统计学意义(P<0.05)。结论盐酸米诺环素预防下颌智齿拔除后干槽症的发生,操作简单,成本低廉,疗效显著。
Objective To observe the efficacy of minocycline hydrochloride in preventing dry mouth disease. Methods From February 2009 to October 2011, 106 patients with under-jaw mandibular wisdom teeth were randomly divided into observation group (53 cases) and control group (53 cases). Observation group after tooth extraction, cut a piece of 2cm × 2cm size bio-stoppour, the surface coated with an appropriate amount of minocycline hydrochloride ointment placed in the extraction socket, bite gauze half an hour. Spit out the gauze after hemostasis, with ointment of hemostatic cotton stay extracted tooth socket, to be its own off; the control group only bite the yarn to stop bleeding, extraction of the socket does not use prophylactic drugs, postoperative oral amoxicillin and metronidazole . Results There was no dry socket in 53 cases in the observation group. After one week of follow-up, the surface of the tooth was completely healed with an effective rate of 100%. In the control group, 5 cases of dry socket occurred in 53 cases, with an effective rate of 90.1%. The two groups were compared, the difference was statistically significant (P <0.05). Conclusion Minocycline hydrochloride can prevent the occurrence of dry trough after extraction of mandibular wisdom teeth, which is easy to operate with low cost and remarkable curative effect.