Since the 1960s, dramatic changes have taken place in land-use patterns characterized by the persistent expansion of cultivated land and a continuous decrease in natural woodland and grassland in the arid inland river basins of China. It is very important to assess the effects of such land-use changes on the hydrological processes so vital for water resource management and sustainable development on the catchment scale. The Maying River catchment, a typical arid inland watershed located in the middle of the Hexi Corridor in northwest China, was the site chosen to investigate the hydrological responses to land-use changes. The annual runoff, base flow, maximum peak flow, and typical seasonal runoff in both spring and autumn flood periods were selected as the variables in the hydrological processes. Statistical-trend analysis and curvilinear regression were utilized to detect the trends in hydrological variables while eliminating the climatic influence. The relationship between cultivated land-use and hydrological variables was analyzed based on four periods of land-use variation data collected since 1965. A runoff model was established composed of two factors, i.e., cultivated land use and precipitation. The impact of land use changes, especially in the large ar- eas of upstream woodland and grassland turned into cultivated lands since 1967, has resulted in a mean annual runoff decrease of 28.12%, a base flow decline of 35.32%, a drop in the maximum peak discharge of 35.77%, and mean discharge decreases in spring and autumn of 36.05% and 24.87% respectively, of which the contribution of cultivated land expansion to the influence of annual runoff amounts to 77%-80%, with the contribution to the influence of spring discharge being 73%-81%, and that to the influence of base flow reaching 62%-65%. Thus, a rational regulation policy of land use patterns is vitally important to the sustainable use of water resources and the proper development of the entire catchment. Since the 1960s, dramatic changes have taken place in land-use patterns characterized by the persistent expansion of cultivated land and a continuous decrease in natural woodland and grassland in the arid inland river basins of China. It is very important to assess the effects of such land-use changes on the hydrological processes so vital for water resource management and sustainable development on the catchment scale. The Maying River catchment, a typical inridate located in the middle of the Hexi Corridor in northwest China, was the site called to investigate the hydrological responses to land-use changes. The annual runoff, base flow, maximum peak flow, and typical seasonal runoff in both spring and autumn flood periods were selected as the variables in the hydrological processes. Statistical-trend analysis and curvilinear regression were utilized to detect the trends in hydrological variables while eliminating the climatic influence. The relationship between cultivate d land-use and hydrological variables was analyzed based on four periods of land-use variation of data collected since 1965. A runoff model was established composed of two factors, ie, cultivated land use and precipitation. The impact of land use changes, especially in the large ar- eas of upstream woodland and grassland turned into cultivated lands since 1967, has resulted in a mean annual runoff decrease of 28.12%, a base flow decline of 35.32%, a drop in the maximum peak discharge of 35.77%, and mean discharge decreases in spring and autumn of 36.05% and 24.87% respectively, of which the contribution of cultivated land expansion to the influence of annual runoff amounts to 77% -80%, with the contribution to the influence of spring discharge being 73% -81 %, and that to the influence of base flow reaching 62% -65%. Thus, a rational regulation policy of land use patterns is vitally important to the sustainable use of water resources and the proper development of the entire catchment.