类固醇麻醉药乙他诺隆(eltanolone)是3α羟基-5β-孕烷-20酮,其药代动力学有性别方面的差异,而且外科手术也影响该药在体内的处置。 乙他诺隆的清除(廓清)主要由人体的新陈代谢,但该药的代谢产物却无药理学方面的作用。经验证明年轻女性廓清乙他诺隆约比年轻男性高40％～50％,而50岁以下的女性 The steroid anesthetic eltanolone is 3α hydroxy-5β-pregnan-20 ketone with a pharmacokinetic profile that varies by gender and that surgery also affects the drug’s in vivo disposal. The elimination of betatrononon (clearance) is mainly by the body’s metabolism, but the drug’s metabolites have no pharmacological effects. Experience has shown that young women profile B metononol about 40% to 50% higher than younger men, while women under 50 years of age