胃肠间质瘤(Gastrointestinal stromal tumor,GIST)是一类相对少见的肿瘤,据国外报道,每年发病率约2/10万[1],占所有胃肿瘤的2%,小肠肿瘤的14%,结肠肿瘤的0.1%,多见于50～70岁,其发病率在性别上无显著性差异。过去受病理诊断技术的限制,一些GIST常被误诊为平滑肌瘤、平滑肌肉瘤及神经纤维瘤。近年随着免疫组化、电镜技术和分子生物学的发展,人们对GIST的认识越来越深入,有关临床报道也 Gastrointestinal stromal tumor (GIST) is a relatively rare type of tumor. According to foreign reports, the incidence of GIST is about 2 / 100,000 [1] per year, accounting for 2% of all gastric tumors, 14% of small intestinal tumors, 0.1% of colon tumors, more common in 50 to 70 years old, the incidence of no significant gender differences. In the past by the limitations of pathological diagnosis techniques, some GIST often misdiagnosed as leiomyoma, leiomyosarcoma and neurofibroma. In recent years, with immunohistochemistry, electron microscopy and molecular biology, people’s understanding of GIST more and more in-depth, clinical reports