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[目的]观察参麦注射液联合西药治疗慢性萎缩性胃炎红细胞免疫功能改善相关性。[方法]使用前瞻性设计方法,将50例住院患者,在泰安市中医医院健康体检者中选择健康对照组35例。健康对照组35例停用一切影响免疫功能药物半个月以上。治疗组50例参麦注射液40m L+5%葡萄糖200m L静滴,1次/d,一般支持治疗,胃黏膜屏障功能加麦滋林-S、硫糖铝;胃排空低下加多潘立酮、莫沙必利;胃酸分泌过多加奥美拉唑和法莫替丁等;CAG合并Hp加胶态铋、抗生素、甲硝唑等。连续治疗14d为1疗程。观测红细胞C3b受体花环率(RBC-C3b RR)、免疫复合物花环率(RBC-ICR)、不良反应。治疗1疗程,判定疗效。[结果]治疗组C3b RR低于对照组(P<0.01,P<0.05),Hp阳性低于Hp阴性、健康对照组(P<0.01),治疗组RBC-ICR高于对照组(P<0.01,P<0.05),Hp阴性组低于Hp阳性(P<0.01)。[结论]参麦注射液联合西药治疗可明显改善红细胞免疫功能,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the effect of Shenmai injection combined with Western medicine in improving erythrocyte immune function of chronic atrophic gastritis. [Methods] Using prospective design method, 35 patients were selected from 50 inpatients and healthy controls in Tai’an Chinese Medicine Hospital. 35 cases of healthy control group to disable all affect immune function drugs for more than half a month. The treatment group 50 cases of Shenmai injection 40m L + 5% glucose 200m L intravenous infusion, 1 times / d, general supportive treatment, gastric mucosal barrier function plus Mezolin-S, sucralfate; gastric emptying plus domperidone, Mosapride; gastric hypersecretion plus omeprazole and famotidine; CAG combined Hp plus colloidal bismuth, antibiotics, metronidazole and so on. Continuous treatment 14d for a course of treatment. The RBC-C3b RR, RBC-ICR, adverse reactions were observed. Treatment of a course of treatment to determine the efficacy. [Results] The C3b RR of the treatment group was lower than that of the control group (P <0.01, P <0.05), but the Hp positive rate was lower than that of the Hp negative group and the healthy control group (P <0.01) , P <0.05), Hp negative group was lower than Hp positive (P <0.01). [Conclusion] Shenmai injection combined with Western medicine can obviously improve the immune function of erythrocytes, with satisfactory curative effect and no serious adverse reactions, which deserves promotion.