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妊娠伴有的血浆蛋白-A(PAPP-A)是新近描述的妊娠蛋白中的一种,母血中该蛋白的浓度随孕龄而增加。已有人提出PAPP-A是由胎盘产生的,但新近的研究提出,胎盘并非PAPP-A的唯一来源,在未孕妇女及男人的血清中也含有低水平的PAPP-A,内膜和蜕膜中的浓度较高。PAPP-A的生理作用尚未完全弄清,离体条件下PAPP-A的纯品具有免疫抑制作用。由于PAPP-A能结合于肝素,提示它也可能参与血凝系统。基于人的精浆具有免疫抑制作用,作者对精浆进行了研究,发现人的精浆中含有一种类PAPP-A的物质,其
Pregnancy associated plasma protein-A (PAPP-A) is one of the newly described gestational proteins whose concentration in maternal blood increases with gestational age. It has been suggested that PAPP-A is produced by the placenta, but recent studies suggest that the placenta is not the only source of PAPP-A and also contains low levels of PAPP-A, intima and decidua in the serum of non-pregnant women and men In the higher concentration. The physiological role of PAPP-A has not yet been fully understood, and the pure product of PAPP-A underwent in vitro immunosuppression. Because PAPP-A binds to heparin, suggesting that it may also participate in the coagulation system. Based on the immunosuppressive effect of human seminal plasma, the authors studied seminal plasma and found that human seminal plasma contains a substance that is a PAPP-A