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羊水量异常是常见的产科疾病,胎儿异常及围产儿发病率、死亡率明显升高[1]。羊水量异常的病理学机制有待阐明,尚无有效防治措施。水通道蛋白(aquaporins,AQPs)是一类分子质量约26~30 ku、对水具有高度特异性的膜内在蛋白,其功能是在细胞膜上形成运输水的跨膜通道,在机体内选择性地表达于与水代谢有关的多种组织和器官。目前国内外陆续有文献报道AQPs参与母胎间的液体交换,与羊水膜内吸收及羊水量的调
Abnormal amniotic fluid is a common obstetric disease, fetal abnormalities and perinatal morbidity, mortality was significantly increased [1]. Abnormal amniotic fluid pathological mechanisms to be clarified, there is no effective prevention and treatment measures. Aquaporins (AQPs) are a class of membrane intrinsic proteins with a molecular mass of about 26-30 ku that are highly specific for water. Their function is to form transmembrane channels of transport water on the cell membrane, selectively Expressed in a variety of tissues and organs related to water metabolism. At home and abroad have reported in succession AQPs involved in maternal fluid exchange between amniotic membrane and amniotic fluid absorption and amniotic fluid adjustment