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目的:研究黄芩总黄酮对肉瘤S180的治疗作用以及黄芩总黄酮与常用化疗药的联合作用。方法:采用抗移植性肿瘤实验方法,观察黄芩总黄酮对移植性肉瘤的干预作用。结果:黄芩总黄酮以5、10和20mg/kg连续8天灌胃给药,对移植性肉瘤S180的抑制率分别为20.46%,33.48%和46.98%(P<0.05);黄芩总黄酮以5、10和20mg/kg连续15日灌胃给药,对S180抑瘤率分别为47.95%,59.06%和62.57%(P<0.001);黄芩总黄酮分别与化疗药物CTX,PDD及5-Fu联合,对治疗S180有良好的协同作用;结论:黄芩总黄酮对S180有良好的抗种瘤作用。
Objective: To study the therapeutic effect of total flavonoids of Astragalus on sarcoma S180 and the combined effect of total flavonoids of Astragalus and commonly used chemotherapeutics. Methods: The anti-tumor tumor experimental method was used to observe the intervention effect of total flavonoids of Astragalus on transplanted sarcoma. RESULTS: Total flavonoids of Astragalus membranaceus were intragastrically administered at 5, 10 and 20 mg/kg for 8 consecutive days. The inhibitory rates of transplanted sarcoma S180 were 20.46%, 33.48% and 46.98%, respectively (P<0.05); At 10, 20 and 20 mg/kg gavage for 15 consecutive days, the tumor inhibition rates for S180 were 47.95%, 59.06%, and 62.57%, respectively (P<0.001); the total flavonoids of Scutellaria baicalensis and chemotherapeutic agents CTX, PDD, and 5-Fu were combined. There is a good synergistic effect on the treatment of S180; Conclusion: The total flavonoids of Astragalus have a good anti-tumor effect on S180.