利福平是高效抗结核药物,国内已广泛应用。由于结核菌接触利福平6小时后即出现延缓生长期而不繁殖,由此看来最适于间歇疗法。但间歇疗法易致急性肾功能衰竭,国内外已有报道。本院三年内收治间断使用利福平引起急性肾功能衰竭3例,1例合并中毒性肝炎,特报道如下。病例报告例1 顾××,女性,39岁,住院号28874。患者因无尿60小时于1979年8月2日入院。患者有肺结核史15年,于1978年3月开始服利福平,入院前4天停药,于1979年7月30日晨又空腹服利福平600mg,当天上午发热,下午呕吐、腹泻,于第2天起尿量减少以至无尿,经当 Rifampicin is highly effective antituberculosis drugs, has been widely used. Mycobacterium tuberculosis appears to be the most suitable for intermittent therapies since it appears to delay growth after 6 hours of exposure to rifampicin and does not reproduce. However, intermittent therapy prone to acute renal failure, both at home and abroad have been reported. Hospital admitted within three years of intermittent use of rifampicin caused acute renal failure in 3 cases, 1 case of toxic hepatitis, especially reported as follows. Case report 1 GU XX, female, 39 years old, hospital number 28874. The patient was admitted to the hospital on August 2, 1979 for having no urine for 60 hours. Patient has a history of pulmonary tuberculosis 15 years, in March 1978 began serving rifampicin, admission 4 days before withdrawal, in the morning of July 30, 1979 morning and fasting rifampin 600mg, the morning fever, afternoon vomiting, diarrhea, On the second day, the amount of urine decreased to no urine, after appropriate