目前大肠癌是我国消化道常见的恶性肿瘤之一,据流行病预测到2000年男性肠癌将占全身恶性肿瘤第一位,女性肠癌将仅次于乳癌占第二位。因此,现在研究肠癌是重要的。本文取材于光镜诊断为大肠腺癌的标本十例。取癌组织及正常粘膜做电镜检查。见正常大肠粘膜表面为单层吸收细胞及杯状细胞,细胞排列整齐,有极性(图1)。大肠腺癌细胞大小形态各异,排列紊乱,核大,异形,极性丧失。癌细胞有暗、亮两型(图2),暗型癌细胞表面有微绒毛,而亮型则微绒毛缺如,有粘液分泌。癌细胞间多为平滑连接,桥粒丰富,常见桥粒分离现象(图3)。暗型癌细胞间有相嵌连接,但指状突起稀少而简单, At present, colorectal cancer is one of the common malignant tumors in our country’s digestive tract. According to the epidemic, it is estimated that male colorectal cancer will take the first place in 2000 with malignant tumors of the body and female colon cancer will be the second only to breast cancer. Therefore, the study of colorectal cancer is important now. This article is based on light microscopic diagnosis of colon adenocarcinoma specimens in 10 cases. Take cancer tissue and normal mucosa electron microscopy. See the normal mucosal surface of the monolayer to absorb cells and goblet cells, cells arranged in neat rows, with polarity (Figure 1). Colorectal cancer cells in different shapes and sizes, arranged in disorder, nuclear large, shaped, polar loss. Cancer cells are dark and bright two types (Figure 2), dark cancer cells have microvilli, while the bright microvilli absence, mucus secretion. Mostly smooth transition between cancer cells, desmosome-rich, common desmosome phenomenon (Figure 3). Dark cancer cells have intercalary connections, but fingers are sparse and simple,