论文部分内容阅读
目的本研究旨在探明3 d航天飞行是否会导致航天员的心脏-压力反射功能及血流动力学参数发生变化。方法在飞行前14 d及返回后第2天,采用SEVE系统以非介入式的逐搏测量技术连续监测航天员做呼吸动作及应激测试时的心电、血压和呼吸信号。通过分析这些生理信号,对航天员自发性压力反射敏感性(SBRs)、心输出量(CO)、每搏量(SV)及总外周血管阻力(TPR)变化进行评价。结果飞行后,航天员的立位耐力评分轻微下降;在基础状态下,飞行导致SBRs和TPR下降,SV和CO升高。在做呼吸动作及应激测试中发现,航天飞行导致收缩压、舒张压、心率(HR)、SV及CO对应激的反应能力下降,而SBRs对应激的反应能力却没有受到影响。结论短期航天飞行导致了基础状态下航天员的SBRs和TPR下降,SV和CO升高,抑制了应激状态下心血管系统的调节功能。
Aims The purpose of this study was to determine if 3-day space flight could lead to astronaut changes in cardiac-baroreflex function and hemodynamic parameters. Methods On the 14th day before flight and the 2nd day after the return, the SEVE system was used to continuously monitor the ECG, blood pressure and respiration signals of astronauts during respiration and stress test by using noninvasive beat-measure technique. By analyzing these physiological signals, the changes of spontaneous SBRs, cardiac output (CO), stroke volume (SV) and total peripheral vascular resistance (TPR) were evaluated. Results After the flight, the astronaut’s standing stamina score decreased slightly; at baseline, the flight resulted in a decrease in SBRs and TPR, and an increase in SV and CO. During respiratory motion and stress tests, it was found that the ability of space flight to cause systolic blood pressure, diastolic blood pressure, heart rate (HR), SV and CO to respond to stress decreased, while the responsiveness of SBRs to stress was unaffected. Conclusions The short-term space flight led to the astronaut’s SBRs and TPR decrease, SV and CO astronauts under the basic condition, and suppressed the cardiovascular system’s regulation function under stress.