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目的：研究放射免疫治疗（ＲＩＴ）对肿瘤转移的预防和治疗作用，寻找一种抑制肿瘤转移的方法。方法：采用１３１Ｉ－Ｃ５０治疗ＬＡ７９５肺腺癌小鼠模型。通过观察治疗前后小鼠的体重减轻量、瘤重、生存期、肺转移数。比较一小鼠接种后不同时间给药分次小剂量ＲＩＴ与化疗、手术及对照组之间疗效差别。二、接种后不同时间截肢后综合治疗对荷瘤小鼠作用。结果：一、接种后第７天给药，各治疗组与对照组比较，体重减轻少、瘤重轻、肺转移结节数少，以分次小剂量ＲＪＴ组最优。接种后第４天给药，与对照组比较疗效进一步提高。二、接种后第１５天手术，分次小剂量５组、化疗组比单次大剂量ＲＩＴ组及对照组小鼠生存期延长，肺转移结节数减少，分次小剂量ＲＩＴ优于化疗。接种后第８天手术，与对照组比较疗效进一步提高，且分次小剂量Ｍ组最优。结论：分次小剂量ＲＩＴ优于单纯化疗、手术；提前给药分次小剂量ＲＩＴ疗效更优；分次小剂量ＲＩＴ结合手术的综合治疗能明显放大小剂量ＲＩＴ的抑瘤效应；尽早实行综合治疗疗效更优。
Objective: To study the preventive and therapeutic effects of radioimmunotherapy (RIT) on tumor metastasis and to find a way to inhibit tumor metastasis. Methods: 131I-C50 LA795 lung adenocarcinoma mouse model was treated. By observing the weight of mice before and after treatment, tumor weight, survival, lung metastases. Comparison of a mouse vaccination at different times after administration of small doses of RIT and chemotherapy, surgery and control group differences in efficacy. Second, at different times after inoculation amputation comprehensive treatment of tumor-bearing mice. Results: First, 7 days after inoculation, each treatment group compared with the control group, less weight loss, tumor weight less, the number of pulmonary metastases less, with small doses of RJT group optimal. On the fourth day after inoculation, the therapeutic effect was further improved compared with the control group. Second, the 15th day after inoculation surgery, small doses of five groups, the chemotherapy group than a single high-dose RIT group and control mice prolonged survival, reduced lung metastasis nodules, small doses of fractionated RIT better than chemotherapy. On the 8th day after inoculation, the curative effect was further improved compared with the control group, and the group M with the best dose was the best. Conclusions: RIT is superior to simple chemotherapy and surgery alone. Early administration of small doses of RIT is more effective. Combined treatment with small doses of RIT can significantly enhance the anti-tumor effect of low-dose RIT. As soon as possible, The curative effect is better.