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为了研究HLA-DR_4基因检测在类风湿关节炎诊治中的意义,对50例类风湿关节炎患者进行了HLA-DR_4的(PCR-SSP方法)检测,同时结合患者的临床表现和实验室指标进行分析。结果显示:HLA-DR_4阳性者31例(阳性率为62％);比较HLA-DR_4阳性和阴性两组患者其他指标,可见,HLA-DR_4阳性组的关节疼痛指数、ESR、类风湿因子(RF)滴度均明显高于HLA-DR_4阴性组(P值分别<0.05或0.01),手腕部X线在Ⅱ级～Ⅲ级异常变化者也以HLA-DR_4阳性组较多(P<0.005)。结果提示:HLA-DR_4基因检测是临床作为类风湿关节炎患者判断病情和估计预后有价值的指标之一,值得进一步探讨。
In order to study the significance of HLA-DR_4 gene detection in the diagnosis and treatment of rheumatoid arthritis, HLA-DR_4 (PCR-SSP method) was performed in 50 patients with rheumatoid arthritis and combined with the clinical manifestations and laboratory parameters analysis. The results showed that there were 31 HLA-DR_4 positive patients (positive rate was 62%). Compared with other HLA-DR_4 positive and negative patients, the joint pain index, ESR, rheumatoid factor (RF) ) Titers were significantly higher than those in HLA-DR_4 negative group (P <0.05 or 0.01, respectively). There were also more HLA-DR_4 positive patients with X-ray abnormalities in grade Ⅱ ~ Ⅲ (P <0.005). The results suggest that the detection of HLA-DR_4 gene is one of the most valuable clinical and prognostic factors in patients with rheumatoid arthritis, which deserves further investigation.