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目的观察非洛地平缓释片和厄贝沙坦对老年高血压左室肥厚和Q-T离散度的影响。方法收集老年高血压伴左室肥厚患者82例,随机分为非洛地平缓释片组和非洛地平缓释片+厄贝沙坦组,治疗前后检测左室舒张期末径(LVDd)、舒张期室间隔厚度(IVSd)、左室后壁厚度(LVPWd)、左室心肌重量(LVM)、左室心肌重量指数(LVMI),以及进行标准12导联心电图检查,测量Q-T间期。结果在降压效果相似的情况下,两组LVMI,Q-Td均比治疗前降低(P<0.01),治疗后两组间LVMI及Q-Td比较差异有统计学意义(P<0.05)。结论非洛地平缓释片和厄贝沙坦联用有协同逆转左室肥厚并能显著降低Q-Td的作用。
Objective To observe the effect of sustained-release felodipine and irbesartan on left ventricular hypertrophy and Q-T dispersion in elderly patients with hypertension. Methods Eighty-two elderly hypertensive patients with left ventricular hypertrophy were collected and randomly divided into felodipine extended-release tablets and felodipine sustained-release tablets plus irbesartan. Before and after treatment, left ventricular diastolic diameter (LVDd) and diastolic (IVSd), left ventricular posterior wall thickness (LVPWd), left ventricular myocardial weight (LVM), left ventricular myocardial mass index (LVMI), and standard 12-lead electrocardiography were used to measure the QT interval. Results LVMI and Q-Td in both groups were lower than those before treatment (P <0.01). The difference of LVMI and Q-Td between the two groups after treatment was statistically significant (P <0.05). Conclusion The combination of felodipine sustained-release tablets and irbesartan can synergistically reverse left ventricular hypertrophy and significantly reduce Q-Td.