作者在东非的部队中以前瞻性随机双盲试验,对化学药物预防疟疾的副作用进行了比较。所用药物为甲氟喹、氯喹和氯胍。按照志愿参加的原则,该项研究在飞行员以外的624名男性士兵中进行。经计算机的随机处理,317名士兵每周服用甲氟喹250mg及2片安慰剂,此外,每天服用2片安慰剂。另307名士兵每周服用氯喹300mg及1片安慰 In a prospective, randomized, double-blind trial of troops in East Africa, the authors compared the side effects of malaria with chemical prophylaxis. The drugs used were mefloquine, chloroquine and proguanil. In accordance with the principle of voluntary participation, the study was conducted among 624 male soldiers outside the pilot. Of the 317 randomized soldiers treated with mefloquine 250 mg and 2 placebo per week by computer randomized treatment, in addition, two placebo tablets were administered daily. The other 307 soldiers took chloroquine 300 mg and 1 tablet a week for comfort