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关于硷式水杨酸铋注射剂的含量测定方法,中国药典是采用称定磷酸铋沉淀重量后再改算成含铋量的方法。其他国家药典(如美国药典、日本药局方)亦系采用此法测定铋的含量。笔者认为,在具体操作中,有二点值得改进,对提高工作效率、简化操作手续、保证检验质量均有帮助,现介绍如下。改进操作之一是:用吸管吸取样品的方法改为称定重量取检品的方法。药典规定:“精密用吸管测出适量,置分液器中,吸管用醚约25ml 洗净,……”。由于本品是一种白色油混悬液,本身具有很大的粘度。若本品浓度为1ml 含0.1g,则须吸取4ml 检品左右,因之,所采用吸管一般为5ml 胖肚吸管或刻度吸管。
About alkaline salicylate bismuth injection content determination method, the Chinese Pharmacopoeia is determined by the weight of bismuth phosphate precipitation and then converted into a method containing bismuth. Other countries Pharmacopoeia (such as the United States Pharmacopoeia, Japanese Pharmacopoeia) also used this method to determine the content of bismuth. The author believes that in the specific operation, there are two points worth improvement, to improve work efficiency, simplify procedures, to ensure the quality of inspection are helpful, are presented below. One of the improvements is to change the method of pipetting a sample into a method of weighing a sample. Pharmacopoeia states: “Precision pipette measured the right amount, set the dispenser, the pipette with ether about 25ml wash, ... ”. Because this product is a white oil suspension, itself has a great viscosity. If the product concentration of 1ml with 0.1g, 4ml seized goods to be about so, the use of straw is generally 5ml fat belly suction pipette or pipette.