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[目的]探讨胰腺实性假乳头状瘤的临床病理特征、诊断及治疗。[方法]分析2例胰腺实性假乳头状瘤的临床病理学、免疫组化,并作相关文献复习。[结果]2例患者均为女性,以腹痛和腹部包块就诊。瘤体直径分别为10.0cm和5.5cm。组织形态学:单形性肿瘤细胞构成实性及假乳头结构,常伴有出血、泡沫细胞和胆固醇裂隙。其中1例肿瘤无完整包膜,局灶浸润周围胰腺组织。免疫表型:α-ACT、Vim、NSE、SYN、PR2例呈阳性,S-100、AE1/AE3、EMA2例呈阴性,LYS、CgA、ER1例呈阳性,另1例呈阴性。2例患者均行手术治疗,术后分别随访3年和2.5年未发现肿瘤复发或转移。[结论]胰腺实性假乳头状瘤诊断和鉴别诊断主要依据临床资料、组织病理学特征和免疫组化研究,手术切除是治疗胰腺实性假乳头状瘤的有效手段。
[Objective] To investigate the clinicopathological features, diagnosis and treatment of solid pseudopapillary tumors of the pancreas. [Method] The clinical pathology and immunohistochemistry of 2 cases of solid pseudopapillary tumor of pancreas were analyzed, and relevant literature reviews. [Results] All 2 patients were female, with abdominal pain and abdominal mass treatment. Tumor diameter were 10.0cm and 5.5cm. Histomorphology: Monomorphic tumor cells constitute a solid and pseudopapillary structure, often accompanied by bleeding, foam cells and cholesterol fissures. One case of tumor without complete capsule, focal infiltration around the pancreas. Immunophenotype: Alpha-ACT, Vim, NSE, SYN, PR2 cases were positive, S-100, AE1 / AE3, EMA2 cases were negative, LYS, CgA, ER1 cases were positive, the other one was negative. Two patients underwent surgical treatment. No recurrence or metastasis was found after 3 years and 2.5 years respectively. [Conclusion] The diagnosis and differential diagnosis of solid pseudopapillary tumors of the pancreas are mainly based on clinical data, histopathological features and immunohistochemical studies. Surgical resection is an effective method for the treatment of solid pseudopapillary tumors of the pancreas.