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目的:对复方荷叶胶囊的入血成分进行分析研究,进而探讨其药效物质基础。方法:采用血清药物化学研究方法,在建立复方荷叶胶囊高效液相色谱指纹图谱的基础上,通过比较复方荷叶胶囊原药、荷叶给药后含药血清、车前草给药后含药血清、番泻叶给药后含药血清、复方荷叶胶囊给药后含药血清、空白血清的液相特征图谱,鉴定复方荷叶胶囊口服给药后的血中移行成分。结果:口服复方荷叶胶囊后,从血清中发现18个入血成分,其中14个为复方荷叶胶囊中原形吸收入血的成分,其余入血成分可能为原形成分的代谢产物。结论:18个入血成分可能是复方荷叶胶囊的体内直接作用物质,对其进行深入研究将有助于为复方荷叶胶囊的药效物质基础及药效机制奠定基础。
OBJECTIVE: To analyze and analyze the blood components of compound lotus leaf capsules, and then to explore its drug substance basis. Methods: Based on the HPLC method of serum medicinal chemistry, based on the HPLC fingerprints of compound lotus leaf lotus capsules, Drug serum, drug-containing serum after senna administration, compound lotus leaf Capsule drug-containing serum, blank serum liquid phase characteristics of the map to identify Compound lotus capsule orally administered blood migration components. RESULTS: Eighteen infusions were found from serum after oral administration of lotus leaf lotion. Among them, 14 were the components that infiltrated into the bloodstream of Fufang lotus capsule, and the rest of the inflow components might be metabolites of the original components. CONCLUSION: Eighteen infusions may be the direct acting substances of compound lotus leaf capsule in-vivo, and in-depth study will help to lay foundation for the pharmacodynamic basis and pharmacodynamic mechanism of compound lotus leaf capsule.