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目的:探讨小儿豉翘清热颗粒辅助西医常规疗法治疗手足口病(HFMD)患儿的临床疗效。方法:选取浙江省嘉兴市第一医院儿科传染科收治的HFMD患儿108例,采用随机数字表法分为观察组和对照组各54例,两组均予常规西医治疗,观察组同时给予豉翘清热颗粒辅助治疗,疗程5天,对比临床效果。结果:观察组患儿治疗后的退热、皮疹消退、口腔溃疡愈合、住院时间均显著短于对照组(P<0.05);治疗后两组患儿血清IL-6、IL-10、TNF-α、INF-γ、IgA、IgG、IgM水平较治疗前均显著降低(P<0.05),治疗后观察组患儿血清IL-6、IL-10、TNF-α、INF-γ水平显著低于对照组(P<0.05);观察组的总有效率为96.30%,显著高于对照组的83.33%(P<0.05)。结论:小儿豉翘清热颗粒辅助西医常规疗法治疗HFMD患儿的疗效优于单纯西医疗法。
Objective: To investigate the clinical efficacy of pediatric Qiqiao Qingre granules in the treatment of children with hand-foot-mouth disease (HFMD). Methods: A total of 108 children with HFMD were enrolled in the First Department of Pediatrics, Jiaxing First Hospital of Zhejiang Province. Fifty-two HFMD patients were divided into observation group and control group by random number table. The two groups were given conventional western medicine. Qiao Qingre granules adjuvant therapy, treatment of 5 days, the clinical effect. Results: After treatment, the fever, rash, ulcer healing and hospital stay in observation group were significantly shorter than those in control group (P <0.05). After treatment, the levels of IL-6, IL-10 and TNF- The levels of IL-6, IL-10, TNF-α and INF-γ in the observation group were significantly lower than those before treatment (P <0.05) (P <0.05). The total effective rate in the observation group was 96.30%, which was significantly higher than that in the control group (83.33%, P <0.05). Conclusion: The therapeutic effect of Xiaoyao Qiaoqing Qingre Granules on Western-style conventional therapies for children with HFMD is better than western medicine alone.