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观察重组γ型干扰素治疗类风湿关节炎 (RA)的疗效。方法 30 3例 RA患者用珠海丽珠生物工程制药厂生产的重组γ型干扰素治疗 ,每周肌注 5天 ,休息 2天 ,每次 1.0 m U,3个月为一个疗程。其中 44例在第 1疗程结束后 ,改为每周肌注 2次 ,每次1.0 m U以巩固疗效 ,共 3个月为第 2疗程。观察治疗前后临床症状、体征 (晨僵时间、关节压痛指数、关节肿胀指数、双手握力 )和实验室检查项目 (血沉、C反应蛋白、类风湿因子、肝、肾功能 )及 X线片 (双手、腕关节 )。结果 治疗 3个月和 6个月总有效率分别为 75 .3%和 88.6 % ,且不良反应轻。结论 重组 γ型干扰素是治疗 RA的一种安全、有效的生物制剂。
To observe the efficacy of recombinant IFN-γ in the treatment of rheumatoid arthritis (RA). Methods Thirty RA patients were treated with recombinant gamma interferon produced by Zhuhai Lizhu Biological Engineering Pharmaceutical Factory. They were intramuscularly injected for 5 days every week for 2 days, each for 1.0 m U for 3 months. 44 patients in the first course of treatment after the end, instead of intramuscular injection twice a week, each 1.0 m U to consolidate the efficacy of a total of 3 months for the second course of treatment. The clinical symptoms and signs (morning stiffness, joint tenderness index, joint swelling index, two-handed grip) and laboratory tests (ESR, C reactive protein, rheumatoid factor, liver and kidney function) and X-ray ,LOL). Results The total effective rates at 3 months and 6 months after treatment were 75.3% and 88.6%, respectively, and the adverse reactions were mild. Conclusion Recombinant γ-interferon is a safe and effective biological preparation for the treatment of RA.