目的评价吲达帕胺联合氨氯地平(络活喜)在老年高血压治疗中的优势。方法观察中国人民解放军北联太原干休所高血压患者50例,随机分为两组,给以吲达帕胺联合氨氯地平口服与安慰剂相比1个月,比较两组间血压控制情况,脑卒中及心血管事件的发生率。结果 A组患者血压控制在SBP<150mmHg(1mmHg=0.133kPa),DBP<90mmHg者72%,P<0.01,A组脑梗死发生率4%,未出现脑出血,心血管事件的发生率8%,而B组脑梗死和脑出血的发生率分别为20%和16%,心血管事件的发生率32%,P<0.05。结论吲达帕胺联合氨氯地平能有效控制老年性高血压,预防心、脑并发症发生,同时安全性极好。 Objective To evaluate the advantages of indapamide combined with amlodipine in the treatment of elderly patients with hypertension. Methods 50 cases of hypertensive patients in the Taiyuan dry-rest hospital of People’s Liberation Army (PLA) were randomly divided into two groups. One month after oral administration of indapamide plus amlodipine compared with placebo, the control of blood pressure , The incidence of stroke and cardiovascular events. Results The blood pressure of group A was controlled at SBP <150mmHg (1mmHg = 0.133kPa), DBP <90mmHg was 72%, P <0.01. The incidence of cerebral infarction in group A was 4%, no cerebral hemorrhage occurred, and the incidence of cardiovascular events was 8% , While the incidence of cerebral infarction and cerebral hemorrhage in group B were 20% and 16% respectively, and the incidence of cardiovascular events was 32%, P <0.05. Conclusion Indapamide combined with amlodipine can effectively control senile hypertension and prevent the occurrence of cardiac and cerebral complications, and at the same time it has excellent safety.