脂质体作为一种药物基因载体已得到广泛应用,然而其仍然具有物理化学稳定性差、易发生团聚、难以多功能化等缺点.通过使用合成的双亲性高分子共轭亚油酸修饰聚赖氨酸(PC)代替小分子磷脂制备的高分子脂质体(PLs),不仅保留了脂质体的优势,并且克服了上述缺点;通过对高分子进行聚乙二醇(PEG)修饰,可使制备的高分子脂质体具有长循环性.结果表明,高分子脂质体粒径为纳米级,具有药物缓释性能、较低的细胞毒性及较高的细胞内吞效率. Liposomes have been widely used as a drug gene carrier, however, they still have the drawbacks of poor physical and chemical stability, easy aggregation, difficult to multi-function, etc. By using the modified amphiphilic conjugated linoleic acid (PC) instead of small molecule phospholipids prepared by the polymer liposomes (PLs), not only retains the advantages of liposomes, and to overcome the above shortcomings; by macromolecule polyethylene glycol (PEG) modification, The prepared polymer liposomes have long cycle.The results show that the size of the polymer liposomes is in the nanometer scale, and has the properties of sustained-release, low cytotoxicity and high endocytosis efficiency.