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我科自1991年10月至1996年2月用卡铂、阿霉素为主的联合化疗方案对71例头颈部恶性肿瘤患者进行治疗，其中能评价近期疗效的48例。48例中，联合化疗总有效率为77．丑％，CR为12．5％，PR为64．6％。对鳞状细胞癌效果尤为显著，CR＋PR为88．5％。毒副作用以脱发为主（81．3％），其次为造血系统毒性（54．2％）及胃肠道反应（50．0％）。以上毒性反应患者均可耐受，且短期内能恢复。化疗当日于静脉内给予枢复宁能有效地抑制胃肠道反应。本组的临床试验结果表明，卡铂是一种有效的广谱抗癌药物，具有化疗指数高，不必水化，毒性低等优点。卡铂与阿毒素等药联合在治疗头颈部鳞癌、腺癌及恶性淋巴瘤中疗效尤为满意，在头颈癌的治疗中有着重要的临床应用价值。
In our department from October 1991 to February 1996, 71 cases of head and neck cancer patients were treated with a combination chemotherapy regimen based on carboplatin and adriamycin. Among them, 48 cases that could evaluate the short-term efficacy were included. In 48 cases, the total effective rate of combination chemotherapy was 77. Ugly%, CR is 12.5%, and PR is 64.6%. The effect of squamous cell carcinoma was particularly significant, CR+PR was 88.5%. The main side effects of hair loss were hair loss (81.3%), followed by hematopoietic toxicity (54.2%) and gastrointestinal reactions (50.0%). Patients with these toxic effects can tolerate and recover in the short term. The intravenous administration of shufuning on the day of chemotherapy effectively suppressed gastrointestinal reactions. The results of clinical trials in this group showed that carboplatin is an effective broad-spectrum anticancer drug with high chemotherapy index, no hydration, and low toxicity. Carboplatin and a toxin and other drugs in the treatment of head and neck squamous cell carcinoma, adenocarcinoma and malignant lymphoma is particularly satisfactory in the treatment of head and neck cancer has important clinical value.