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目的探讨磷酸铝凝胶预防静脉应用阿奇霉素胃肠道反应的临床疗效。方法将2012年1～8月在我院儿科门诊静脉滴注阿奇霉素治疗的患儿100例,随机分为两组:治疗组50例和对照组50例,治疗组在静脉滴注阿奇霉素30min前口服硫酸铝凝胶1次,药物剂量为2～4岁10g/次;5～14岁20g/次;对照组予口服等量矿泉水治疗。对两组是否出现胃肠道反应及胃肠道反应结果进行观察。结果两组胃肠道反应发生率比较差异有统计学意义(χ2=14.29,P<0.01),治疗组静脉滴注阿奇霉素时的胃肠道反应较对照组轻。结论口服磷酸铝凝胶可有效预防静脉应用阿奇霉素时的胃肠道反应。
Objective To investigate the clinical efficacy of aluminum phosphate gel in the prevention of intravenous azithromycin gastrointestinal reaction. Methods From January to August 2012, 100 pediatric patients treated with azithromycin in pediatric outpatient department of our hospital were randomly divided into two groups: 50 in the treatment group and 50 in the control group. The treatment group was orally administered with azithromycin 30 min before intravenous infusion Aluminum sulfate gel 1 times, the drug dose is 2 to 4 years old 10g / time; 5 to 14 years old 20g / times; the control group to oral equal amount of mineral water treatment. Gastrointestinal reactions and gastrointestinal reactions were observed in both groups. Results There was significant difference in the incidence of gastrointestinal reactions between the two groups (χ2 = 14.29, P <0.01). The gastrointestinal reactions in the treatment group were less than those in the control group. Conclusion Oral aluminum phosphate gel can effectively prevent the gastrointestinal reaction when using azithromycin intravenously.