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三、肝癌标志物1.甲胎蛋白(AFP)AFP 仍为目前公认的最有价值的肝癌标志物,国内外大多学者认为诊断原发性肝癌的标准AFP>400 ng/ml,但最近汤剑猷等认为AFP 持续升高在200ng/ml 以上达8周,可诊断为原发性肝癌即有手术探查适应症。原发性肝癌患者中有20~30%AFP 阴性(<20ng/ml)与低含量(20~200ng/ml),可能由于肝癌细胞分化程度不同,合成AFP 量多少不一致有关。不少良性肝脏疾病如肝炎,肝硬化以及胃肠道肿瘤等血清AFP 常有低含量,因此与肝癌的鉴别诊断带来困难。最近报告进一步分离AFP 的异质体(Varint)
Third, the liver cancer markers 1. AFP (AFP) is still recognized as the most valuable liver cancer markers, most scholars at home and abroad that the standard diagnosis of primary liver cancer AFP> 400 ng / ml, but recently such as Soup Swordfish That AFP continued to rise above 200ng / ml for up to 8 weeks, can be diagnosed with primary liver cancer that surgical exploration indications. 20-30% of AFP negative (<20ng / ml) and low content (20-200ng / ml) of patients with primary liver cancer may be due to the different degree of differentiation of liver cancer cells, the amount of synthetic AFP is inconsistent. Many benign liver diseases such as hepatitis, cirrhosis and gastrointestinal cancer serum AFP often low levels, so the differential diagnosis of liver cancer difficult. Recently reported further isolation of AFP heterogeneous bodies (Varint)