【摘 要】
：
Bufalin is efficacious in treating various tumors,however,the clinical application of which is restricted by the myocardial toxicity.Developing a smart synergetic delivery system is widely considered as a promising therapeutic strategy.To address this iss
【机 构】
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Cardiology Department of Panyu Central Hospital,Guangzhou University of Chinese Medicine,Guangzhou 5
论文部分内容阅读
Bufalin is efficacious in treating various tumors,however,the clinical application of which is restricted by the myocardial toxicity.Developing a smart synergetic delivery system is widely considered as a promising therapeutic strategy.To address this issue,a black phosphorus hybrid polypeptides hydrogel was designed to highly load bufalin,and achieved near-infrared (NIR)-controllable drug release with synergistic photothermal-chemo therapeutic effect.Black phosphorus nanosheets (BPNSs) and bufalin were co-loaded in temperature-sensitive supramolecular hydrogel to receive smart hybridization (BP-bufalin@SH).With NIR irradiation(1 W·cm-2),BP-bufalin@SH exhibited a rapid and large temperature increase and released bufalin via light-controllable manner,with which the side effects of bufalin were greatly decreased.Combined with photothermal-chemo therapeutic effect,BP-bufalin@SH could collapse the mitochondrial transmembrane potential resulting in the irreversible apoptosis of tumor cells,and realize a highly efficient in vivo tumor elimination with good biosafety and biocompatibility.This work provides a new hydrogel platform for controlling bufalin release,and thus further promotes the practical application on antitumor therapy.
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