目的 探讨围绝经期综合征患者应用综合护理干预的效果?方法 随机将2018年4月至2021年4月于我院治疗的160例围绝经期综合征患者分为观察组(n=80，实施综合护理)和(n=80，实施常规护理)，比较不同护理的效果?结果 护理后，观察组的睡眠质量和生活质量评分改善优于对照组，差异有统计学意义(P<0.001);护理后，观察组的血清性激素水平改善优于对照组，差异有统计学意义(P<0.001);观察组护理后的焦虑情绪?抑郁情绪改善效果明显比对照组更好，差异有统计学意义(P<0.05);观察组(3例，占3.7“,”Objective To discuss the effect of comprehensive nursing intervention in patients with perimenopausal syndrome. Methods A total of 160 patients with perimenopausal syndrome from April 2018 to April 2021 to be treated in our hospital were randomly divided into observation group and control group， with an average of 80 cases. A group of observation groups that implement comprehensive care， and those that implement conventional care as the control group，compare the effects of different care. Results After nursing， the sleep quality and quality of life scores of the observation group improved better than those of the control group， and the difference was statistically significant (P<0.001).After nursing， the improvement of serum sex hormone levels in the observation group was better than that of the control group， the difference was statistically significant (P<0.001). The effect of improving anxiety and depression in the observation group after nursing was significantly better than that of the control group， and the difference was statistically significant (P<0.05). The complication rate of the observation group (3 cases， accounting for 3.75%) was significantly lower than that of the control group (14 cases， accounting for 17.50%)， and the difference was statistically significant (P<0.05). Hot flashes after nursing in the observation group sweating， emotional instability， heart palpitations， insomnia， loss of libido and other symptoms are better than the control group， the difference is statistically significant (P<0.05). Observation group (77 cases， 96.25%) overall after nursing satisfaction was significantly higher than that of the control group (69 cases， 86.25%) (P<0.05). Conclusion Intervention for patients with perimenopausal syndrome through comprehensive nursing care can effectively improve their sleep quality and quality of life， promote the adjustment of serum sex hormone levels， improve patients\' anxiety and depression， reduce the incidence of complications， and improve patients\' relatedness Symptoms and improve overall satisfaction.