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目的观察小剂量苯那普利和缬沙坦联合治疗合并高血压的糖尿病肾病的疗效。方法将78例合并高血压的糖尿病肾病患者随机分为联合治疗组(苯那普利5mg/d+缬沙坦80mg/d)、苯那普利组(苯那普利10mg/d)和缬沙坦组(缬沙坦80mg/d),观察期12周。治疗前后检测血压、血糖(BG)、尿白蛋白排泄率(UAER)、血清肌酐(SCr)、尿素氮(BuN)、糖化血红蛋白(HbA1C)、血钾(SK+)。结果3组治疗前后血糖、血清钾、肾功能差异无显著性,但治疗后尿白蛋白排泄率和血压均较治疗前明显下降(P<0.01)。各组间比较,联合治疗组尿白蛋白排泄率下降更明显(P<0.05),单独治疗组间比较差异无显著性。结论小剂量苯那普利和缬沙坦联合治疗合并高血压的早期糖尿病肾病疗效显著,安全合理。
Objective To observe the effect of low-dose benazepril and valsartan in the treatment of diabetic nephropathy with hypertension. Methods 78 patients with diabetic nephropathy with hypertension were randomly divided into combined treatment group (benazepril 5mg / d + valsartan 80mg / d), benazepril group (benazepril 10mg / d) and valsartan Tan group (valsartan 80mg / d), observation period of 12 weeks. Blood pressure, blood glucose (BG), urinary albumin excretion rate (UAER), serum creatinine (SCr), blood urea nitrogen (BuN), HbA1C and SK + were measured before and after treatment. Results Before and after treatment, there was no significant difference in blood glucose, serum potassium and renal function, but the urinary albumin excretion rate and blood pressure were significantly decreased after treatment (P <0.01). Compared between groups, the combination of urinary albumin excretion rate decreased more significantly (P <0.05), the treatment group was no significant difference. Conclusion The combination of low-dose benazepril and valsartan in the treatment of early diabetic nephropathy with hypertension has a significant and safe therapeutic effect.