论文部分内容阅读
胰岛素放射免疫测定虽已广泛用于临床与实验研究,但对已应用胰岛素治疗的糖尿病患者则用处较少;因牛或猪胰岛素反复注射可产生胰岛素抗体,而这些动物胰岛素与人胰岛素有相同的免疫性。因而干扰了胰岛素测定。C肽与胰岛素以等克分子浓度从胰腺β细胞释放,血浆C肽浓度可以反映β细胞的分泌活性;由于胰岛素抗体与C肽不起交叉反应,药用胰岛素均不含C肽,故胰岛素抗体与外源性胰岛素均不影响C肽免疫测定。因而,C肽测定是研究β细胞功能的一种有重要意义的新方法,有利于糖尿病与涉及糖代谢疾患研究的深入开展。
Insulin radioimmunoassay has been widely used in clinical and experimental studies, but has been less effective in patients with diabetes who have been treated with insulin. Repeated injections of bovine or porcine insulin produce insulin antibodies that are identical to human insulin Immune. Thus interfering with the insulin assay. C peptide and insulin in equal molar concentrations from the release of pancreatic β cells, plasma C-peptide concentration reflects the secretion of β-cell activity; insulin antibodies and C peptide cross-reactivity, the use of insulin-free C peptide, so the insulin antibody Neither exogenous insulin nor C peptide immunoassay. Therefore, C-peptide assay is a new and important method to study the function of β cells, which is beneficial to the further development of diabetes and research involving glucose metabolism disorders.