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目的研究吲达帕胺联合氨氯地平治疗高血压合并冠心病的临床效果。方法 84例高血压合并冠心病患者,随机分为观察组和对照组,各42例。对照组给予硝苯地平片治疗,观察组给予吲达帕胺联合氨氯地平治疗,对比两组临床效果及不良发应发生情况。结果观察组高血压和心绞痛治疗总有效率(90.48%、80.95%)显著高于对照组(59.52%、57.14%),差异有统计学意义(P<0.05);观察组治疗后的低浓度脂蛋白(LDL)、高浓度脂蛋白(HDL)、三酰甘油(TG)及总胆固醇(TC)均优于对照组(P<0.05);两组不良反应发生情况比较,差异无统计学意义(P>0.05)。结论对高血压合并冠心病患者采用吲达帕胺联合氨氯地平治疗,效果良好,且安全性高,值得推广和应用。
Objective To study the clinical effect of indapamide combined with amlodipine in the treatment of patients with hypertension and coronary heart disease. Methods Eighty-four patients with hypertension and coronary heart disease were randomly divided into observation group and control group, with 42 cases in each group. The control group was treated with nifedipine tablets. The observation group was treated with indapamide and amlodipine. The clinical effects and incidence of adverse reactions were compared between the two groups. Results The total effective rate (90.48%, 80.95%) of observation group was significantly higher than that of control group (59.52%, 57.14%), the difference was statistically significant (P <0.05) (LDL), high density lipoprotein (HDL), triglyceride (TG) and total cholesterol (TC) were superior to those of the control group (P <0.05). There was no significant difference in adverse reactions between the two groups P> 0.05). Conclusions Indapamide combined with amlodipine in patients with hypertension and coronary heart disease is effective and safe. It is worthy of promotion and application.