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目的探讨长春新碱和环磷酰胺治疗激素依赖型肾病综合征疗效。方法选择我院2008年3月-2011年3月肾病综合征患者60例分为观察组和对照组。两组患者在改善症状的基础治疗上均给予激素治疗,每天给予强的松30-45g,分3次服用。观察组给予长春新碱。长春新碱总剂量为1个疗程10-14mg。对照组患者对症治疗和应用激素同观察组,同时给药环磷酰胺,8-12mg/kg,加入生理盐水注射液200ml中静脉滴注,同时按照20ml/kg水化,1次/d,连续2d为1个疗程,每月治疗1个疗程。对两组治疗后临床疗效进行评定。结果观察组临床总有效率为90.0%,对照组临床总有效率为93.3%,两组比较,差异无统计学意义(P>0.05)。结论长春新碱和环磷酰胺治疗激素依赖型肾病综合征疗效近似,均值得借鉴。
Objective To investigate the effect of vincristine and cyclophosphamide in the treatment of hormone-dependent nephrotic syndrome. Methods Sixty patients with nephrotic syndrome in our hospital from March 2008 to March 2011 were divided into observation group and control group. Both groups were given hormonal therapy on the basis of improvement of symptoms, and given prednisone 30-45g daily for 3 times. The observation group was given vincristine. Vincristine total dose of a course of 10-14mg. The patients in the control group were treated with symptomatic treatment and the same hormone as the observation group. At the same time, cyclophosphamide (8-12 mg / kg) was given intravenously to 200 ml of normal saline injection and hydrated at 20 ml / kg for 1 time / d 2d for a course of treatment, a course of treatment per month. The clinical efficacy of the two groups after treatment was assessed. Results The total clinical effective rate was 90.0% in the observation group and 93.3% in the control group. There was no significant difference between the two groups (P> 0.05). Conclusion Vincristine and cyclophosphamide in the treatment of hormone-dependent nephrotic syndrome similar efficacy, are worth learning from.